سال انتشار: ۱۳۹۳
محل انتشار: همایش ملی شیمی پاک
تعداد صفحات: ۴
Ameneh Fallahtalab Gohary – Department of Chemistry, Islamic Azad University, Rasht Branch, Iran
Manouchehr Mamaghani – Department of Chemistry, Islamic Azad University, Rasht Branch, Iran
Pyrimido pyrimidin are important compounds because of their biological properties whichare known to depend mainly on the nature and position of the substituent [ 1]. Pyrimidopyrimidin derivatives display a broad range of biological activities such as antineoplastic[2-3], antiviral , antibiotic  and anti-inflammatory  including other biologicalactivities. Pyrimidines exhibit a range of pharmacological activity such as antibacterial ,antifungal , anticancer , anti-inflammatory  and cardioprotective effects .Following our continued interests in the synthesis of biologically important heterocycles inthis research, we wish to report a very simple and highly efficient one-pot method for thesynthesis of novel pyrimido pyrimidin via a three-component cyclo condensation ofequimolar amounts of 1,3-indanedione ،aromatic aldehydes and 6-amino-2-(ethylthio)pyrimidin-4(3H)-one derivatives in the presence of ionic liquid [hmim][HSO4] (Scheme 1). This efficient method furnished the desired products (4a-f) in high yields (85-97%) andreaction times (20-50 min). High yields and ease of recovery and reusability of ionic liquidwith consistent activity, makes this protocol efficient and environmentally benign.